曹洁，教授，博士生导师，海燕策略线路1book副院长

学习经历

2004.09-2008.06中国药科大学生物工程专业，本科

2008.09-2013.06 中国药科大学微生物与生化药学专业，硕博连读。导师：顾月清教授

工作经历

2013.8-2015.07 Washington University in St. Louis医学院分子影像中心,博士后研究员

2016.09月-至今 海燕策略线路1book，特聘教授

个人简介：曹洁，教授，博士生导师，海燕策略线路1book副院长，山东省泰山学者青年专家，山东省优秀青年基金获得者。兼任山东省药学会药剂学分会委员，山东省医学会医学教育分会委员。主要研究方向为新型药用功能材料及肿瘤、骨关节炎等疾病的光学治疗及免疫治疗。已在ACS Nano, Advanced Science,Cancer Research,Biomaterials, Chemical Engineering Journal, NPG Asia Materials等国际权威期刊发表学术论文60余篇；主持国家自然科学基金面上项目、科技部青年重大专项、山东省自然科学基金优秀青年项目、面上项目等国家及省部级科研项目10余项；参与科技部重点研发计划、国家自然科学基金重点项目、中韩合作项目及海外青年基金等国家级项目8项；申请国家发明专利5项，授权3项，成果转化1项；英文论著1部。获江苏省优秀博士学位论文，青岛市科技进步二等奖。指导国家级大学生创新创业项目1项，指导本科生在教育部药学类教学指导委员会举办的“全国大学生药苑论坛”、“全国医药院校药学/中药学专业大学生实验技能竞赛”等国家级及省部级创新创业比赛中获得一等奖7项，二等奖12项。

目前主要研究方向：

1.近红外光敏剂的设计与开发

2.新型药用功能材料的设计与开发

3.肿瘤、骨关节炎等疾病的光动力学免疫治疗

近期代表性成果

1.Yifan Zhao, Min Zhang, Bai Lv, Guanghe Xue, Huimei Jiang, Gang Chen, Yi Ma, Yong Sun,Jie Cao*. “Closed-loop” O₂-economizer inducedin situtherapeutic vaccine against hypoxic tumors.ACS Nano2023, 17(21):21170-21181.

2.Min Zhang, Renshuai Zhang, Yunxia Dong, Jiangjun Liu, Zhen Gao, Xinyu Zhou,Jie Cao*. Oxygen supplementation liposomes for rheumatoid arthritis treatment via synergistic phototherapy and repolarization of M1-to-M2 macrophages.Chemical Engineering Journal2023, 459: 141484.

3.Yuyun Ye, Hongli Yu, Bohan Chen, Yifan Zhao, Bai Lv, Guanghe Xue, Yong Sun*,Jie Cao*. Engineering nanoenzymes integrating Iron-based metal organic frameworks with Pt nanoparticles for enhanced Photodynamic-Ferroptosis therapy.Journal of Colloid and Interface Science2023, 645: 882–894.

4.Yifan Zhao, Bai Lv, Guanghe Xue, Yong Sun*,Jie Cao*. Smart Nanosystem-Mediated Inhibition of Mitochondrial Respiration for Enhanced Phototherapy-Induced Antitumor Immunity.International Journal of Nanomedicine2023,18:3443–3457

5.Min Zhang, Yifan Zhao, He Ma, Yusong Sun,Jie Cao*. How to improve photodynamic therapy-induced antitumor immunity for cancer treatment.Theranostics2022, 12(10): 4629-4655.

6.Zijun Shen, Qingming Ma, Xinyu Zhou, Guimin Zhang, Guizhou Hao, Yong Sun,Jie Cao*. Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment.NPG Asia Materials2021, 13:39.

7.Zijun Shen, Junfei Xia, Qingming Ma, Wei Zhu, Zhen Gao, Shangcong Han, Yan Liang,Jie Cao*, Yong Sun. Tumor microenvironment-triggered nanosystems as dual-relief tumor hypoxia immunomodulators for enhanced phototherapy.Theranostics2020, 10(20):9132-52.

8.Jinnan Chi#, Qingming Ma#, Zijun Shen, Caiyun Ma, Wei Zhu, Shangcong Han, Yan Liang,Jie Cao*, Yong Sun. Targeted nanocarriers based on iodinated-cyanine dyes as immunomodulators for synergistic phototherapy.Nanoscale2020, 12 (20):11008-11025. (Back outside cover)

9.Jie Cao*, Jinnan Chi, Junfei Xia, Yanru Zhang, Shangcong Han, Yong Sun*. Iodinated-cyanine dyes for fast NIR-guided deep-tissue synergistic phototherapy.ACS Appl Mater Inter2019, 11(29):25720-25729.

10.发明专利：一种近红外染料，授权公告号：CN 108624080 B，授权日：2020.3.10

电话: 0532-82991508

邮箱: caojie0829@qdu.edu.cn