冀立霞,副教授,硕士生导师
学习经历
2006.09-2009.07中国医学科学院&北京协和医学院药物研究所药理学专业,博士
2003.09-2006.07潍坊医学院 药理学专业,硕士
1998.09-2003.07潍坊医学院 临床医学专业,本科
工作经历
2017.03月-至今 海燕策略线路1book 海燕策略线路1book,副教授
2015.08-2017.12中国第24批援坦桑尼亚医疗队坦桑尼亚MUHAS大学客座教授
2009.11-2017.02海燕策略线路1book 海燕策略线路1book,讲师
个人简介(尽量不超过300字):职称,职务。社会兼职。主要研究领域,课题、项目、论文、专利、获奖情况,获得的主要荣誉等。
冀立霞,副教授,药理学专业,一直从事糖尿病相关的机制及药物研究。目前主要关注两点,一是妊娠糖尿病,研究妊娠糖尿病在糖尿病代际相传中的关键作用;二是抗肥胖相关糖尿病的药物研发,从日常饮食、天然提取物及化合物中筛选能够有效预防或治疗肥胖相关糖尿病的有效成分,从整体和离体水平系统考察其对肥胖致胰岛素抵抗及胰岛功能分化的影响,并进行机制探讨。目前主持国自然面上项目一项,发表SCI收录论文十余篇,申请专利2项。
目前主要研究方向:
1.妊娠糖尿病
2.抗糖尿病药物的研发
主要科研项目(近5年):
1.国家自然科学基金面上项目,妊娠糖尿病脐静脉血外泌体借力PI3K-AktFoxO/mTORC1通路致子代胰岛胚胎期发育成熟异常的研究,2023-2026,主持
2.国家自然科学基金面上项目,海绵Stylissa massa靶向醛糖还原酶ALR2的生物碱成分高效发现及作用机制研究,在研,参与
代表性论文和专著(近5年):
1. Linhai Zou , Chunxue Xu, Li Wang, Xiangju Cao, Xinyu Jia, Zhihong Yang, Guohui Jiang, Lixia Ji*. Human gestational diabetes mellitus–derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets. Life Sciences 2024,342:122514.
2. Ruixin Hu, Linhai Zou, Li Wang, Chunxue Xu, Mengmeng Qi, Zhihong Yang, Guohui Jiang*, Lixia Ji*. Probiotics alleviate maternal metabolic disorders and offspring-islet abnormalities in gestational diabetic mice. Journal of Functional Foods, 2022,99: 105300.
3. Ji Zhou; Xiaoyi Zhang; Lixia Ji*;Guohui Jiang* ; Identification of potential biomarkers of type 2 diabetes mellitusrelated immune infiltration using weighted gene co-expression network analysis, BioMed Research International, 2022: 9920744.
4. Susu Chen, Wenyan Wang, Qilong Cao, Shen Wu, Ningli Wang, Lixia Ji*, Wei Zhu*.Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch.Frontiers in Pharmacology. 2022,13:881286.
5. Ruixin Hu, Yanting Yuan, Chaolong Liu, Ji Zhou, Lixia Ji*, Guohui Jiang*.Newinsightsintothelinksbetweenanti-diabetesdrugsandgutmicrobiota.Endocrine Connections.Endocr Connect.2021,10: R36–R42.
6. Yanting Yuan; Ji Zhou; Ruixin Hu; Linhai Zou; Lixia Ji*;Guohui Jiang* Piperine protects against pancreatic β-cell dysfunction by alleviating macrophage inflammation in obese mice., Life sciences, 2021, 274: 119312.
7. ChaolongLiu, YantingYuan, JiZhou, RuixinHu, LixiaJi*,GuohuiJiang*. Piperine ameliorates insulin resistance via inhibiting metabolic inflammation in monosodium glutamate-treated obese mice. BMC Endocrine Disorders, 2020.20:152.
8. Lixia Ji, Chaolong Liu, Yanting Yuan, Hui Gao, Zhenxue Tang,Zhihong Yang, Zhantao Liu, Guohui Jiang*.Key roles of Rho GTPases, YAP and Mutant P53 in Anti-neoplastic Effects of Stantins.Fundamental andClinicalPharmacology.2019.12495
9. Zhenxue Tang, Qingxia Ma, Luyao Wang, Chaolong Liu,HuiGao, Zhihong Yang,Zhantao Liu, Huimin Zhang, Lixia Ji*, Guohui Jiang*.A brief review: some compoundstargetingYAP against malignancies. Future oncology, 2019:0035 .
电话: 15063930201
邮箱: lixiaji@163.com