姓名：王哲，博士，海燕策略线路1book讲师

学习经历

2018.09-2022.06中国海洋大学，药物化学，博士

2015.09-2018.06山东大学，药物化学，硕士

2011.09-2015.06山东大学，药学，本科

工作经历

2024.07-至今 海燕策略线路1book，讲师

2022.07-2024.07海燕策略线路1book药学流动站，博士后

个人简介

王哲，博士，海燕策略线路1book药理系讲师。主要研究领域为靶向磷酸二酯酶（PDE）小分子抑制剂的发现和药理作用的研究以及海洋天然产物分离和活性研究，构建了PDE抑制剂筛选的新方法，首次发现多种海洋天然小分子具有良好的PDE抑制活性，另外结合计算机虚拟筛选技术，发现了首个PDE7A选择性抑制剂。目前已在Chinese Journal of Chemistry，Journal of Natural Products，Phytochemistry以及Biosensors等杂志上发表SCI文章十余篇。

研究领域方向

1.靶向PDE小分子抑制剂的发现

2.新型PDE抑制剂药理作用的研究

3.海洋天然产物分离及其PDE抑制活性研究

4.基于计算机方法（CADD和AIDD）选择性PDE抑制剂的高效发现

代表性研究成果

1. Zhe Wang^†, Xiao Han^†, Guoping Liu, et al. Kalihioxepanes A-G: Seven Kalihinene Diterpenoids from Marine SpongeAcanthella cavernosaCollected off the South China Sea,Chinese Journal of Chemistry, 2022, 40: 1785-1792.

2. Zhe Wang^†, Yueying Li^†, Xiao Han, et al. Kalihiacyloxyamide A-H,α-Acyloxy Amide Substituted Kalihinane Diterpenes Isolated from the SpongeAcanthella cavernosaCollected in the South China Sea,Phytochemistry, 2023, 206: 113512.

3.Xiao Han^†,Zhe Wang^†, Anran Fu, et al. Clavukoelloids A-M, Thirteen rare N-Containing Nardosinane type Sesquiterpenoids from the Soft CoralClavularia koellikeri,Chinese Journal of Chemistry, 2023, 41: 1491-1496.

4.Zhe Wang, Guoqiang Li, Hanting Zhang, et al. Suberitolactams A-D and Suberitopyridines A-B: Newγ-lactam and Pyridine Alkaloids Isolated from the South China Sea SpongePseudospongosorites suberitoides,Chemistry & Biodiversity, 2024, e202400939.

5.Chunhua Gao^†,Zhe Wang^†, Xiaojing Liu, et al. The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors,Biosensors, 2024, 14: 252.

6.Di Zhang^†,Zhe Wang^†, Xiao Han, et al. Four Bioactive New Steroids from the Soft CoralLobophytum pauciflorumCollected in South China Sea,Beilstein Journal of Organic Chemistry, 2022, 18: 374-380.

7.Zhe Wang, Aihong Peng, Dandan Lu, et al. Manumycin-type Derivatives from aStreptomycessp. Associated with Meson Bee Osmia cornifrons,Natural Product Communications, 2018, 13 (6): 673-676.

联系方式

邮箱：wangzhe@qdu.edu.cn